ULTRASTRUCTURAL CHANGED OF INTRACELLULAR ORGANELLES UPON APOPTOSIS

Е.С. Снигиревская, Я.Ю. Комиссарчик

Abstract


Cell death caused by the genetically determined processes known as apoptosis is implicated not only in embryogenesis and cell and tissue turnover but also in the pathogenesis of many diseases including those induced by environmental factors and may be directly induces by some of the latter. In recent years, the elucidation of the molecular mechanisms of apoptosis was taking the central stage as reflected in a numerous reviews. The present review is focused on recent data about the ultrustructural features of cellular organelles upon apoptosis, including first of all the rearrangements of the interchromatin intranuclear space and the involvement of the ubiquitin-proteasome system in apoptosis.

Keywords


apoptosis, intracellular organelles, ultrastructure, chromatin, electron microscopy, ubiquitin-proteasome system.

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DOI: http://dx.doi.org/10.24855/biosfera.v10i2.440

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