А.Б. Жебрун


The bacterium Helicobacter pylori is the etiopathogenic agent of a number “gastric”, including stomach cancer, and “extragastric” conditions, which affects more than 50% of global population. The duration of evolution of this microorganism in the human population exceeds 100 thousand years. The current H. pylori epidemic is characterized with three features: 1) age-dependent infection rate; 2) slow spontaneous recovery from infection; 3) and the reinfection of a part of recovered population. The resultant of these three processes leads to a gradual decrease in H. pylori prevalence in the developed countries. Russia joined this decrease in the last three years. In the developing countries, persistently high prevalence and high mortality of diseases associated with H. pylori are still evident. The present articles reviews the risk factors of H. pylori infection and its synergistic and antagonistic factors and approaches to controlling the infection. Urgent challenges to medical sciences include the development of a vaccine against H. pylori and the determination of indications for large-scale preventive drug interventions. It is concluded that medical sciences and therapeutic measures significantly contribute to freeing the humankind of H. pylori; however, the leading roles in coming to this end currently belong to the quality of life and public and personal hygiene and to the culture of household, nutrition, drinking, services sector, and interpersonal contacts.


Helicobacter pylori, gastric ulcer, duodenal ulcer, gastric cancer, risk factors.


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DOI: http://dx.doi.org/10.24855/biosfera.v7i2.62


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