SCRUTINIZING THE EPIGENETICS REVOLUTION

М. Мелони, Дж. Теста

Abstract


This is a Russian translation published by the permission of the authors of the original, which appeared under open access terms in BioSocieties (2014) 9, 431–456 and must be referenced upon citing the present translation. The original abstract and full text are available at http://www.palgrave-journals.com/biosoc/journal/v9/n4/abs/biosoc201422a.html (doi:10.1057/biosoc.2014.22).

Keywords


epigenetics; imaginaries; molecularization; plasticity; responsibility; social policy.

References


Abyzov, A. et al. (2012) Somatic copy number mosaicism in human skin revealed by induced pluripotent stem cells. Nature 492(7429): 438–442.

Bechtel, W. (2008) Mental Mechanisms. Philosophical Perspectives on Cognitive Neuroscience . New York: Routledge.

Beck, S. and Niewohner, J. (2006) Somatographic investigations across levels of complexity. BioSocieties 1(2):219-27.

Bird, A. (2007) Perceptions of epigenetics. Nature 447(7413):396-8.

Boniolo, G. and Testa, G. (2011) The identity of living beings, Epigenetics, and the modesty of philosophy. Erkenntnis 76(2):279-98.

Borup, M., Brown, N., Konrad, K. and Van Lente, H. (2006) The sociology of expectations in science and technology. Technology Analysis & Strategic Management 18(3/4):285-98.

Bowler, P. (1984) E. W. MacBride’s Lamarckian eugenics and its implications for the social construction of scientific knowledge. Annals of Science 41(3):245-60.

Brante, T., Fuller, S. and Lynch, W. (1993) Controversial Science: From Content to Contention . New York: SUNY Press.

Brown, N. and Michael, M. (2003) A sociology of expectations: Retrospecting prospects and prospecting retrospects. Technology Analysis and Strategic Management 15(1):3-18.

Brown, N., Rappert, B. and Webster, A. (eds.) (2000) Contested Futures: A Sociology of Prospective Technoscience. Aldershot, UK: Ashgate.

Burrell, R.A., McGranahan, N., Bartek, J. and Swanton, C. (2013) The causes and consequences of genetic heterogeneity in cancer evolution. Nature 501(7467): 338-45.

Carey, N. (2012) The Epigenetics Revolution: How Modern Biology is Rewriting our Understanding of Genetics, Disease, and Inheritance. New York: Columbia University Press.

Chadwick, R. and O’Connor, A. (2013) Epigenetics and personalized medicine: Prospects and ethical issues. Personalized Medicine 10(5):463- 471.

Champagne, F. (2010) Epigenetic influence of social experiences across the lifespan. Developmental Psychobiology 52(4):299-311.

Chan, T.L. et al. (2006) Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer. Nature Genetics 38(10):1178-83.

Choi, S.-W. and Friso, S. (2010) Epigenetics: A new bridge between nutrition and health. Advances in Nutrition 1(1):8-16.

Church, D. (2007) The Genie in Your Genes: Epigenetic Medicine and the New Biology of Intention . Santa Rosa, CA: Elite Books.

Cloud, J. (2010) Why your DNA isn’t your destiny. Time Magazine 6 January.

Crick, F.H.C. (1958) On protein synthesis. Symposia of the Society for Experimental Biology XII:139-63.

Davey Smith, G. (2012) Epigenetics for the masses: More than Audrey Hepburn and yellow mice? International Journal of Epidemiology 41(1):303-8.

Dawkins, R. (1976) The Selfish Gene. New York: Oxford University Press.

Daxinger, L. and Whitelaw, E. (2012) Understanding transgenerational epigenetic inheritance via the gametes in mammals. Nature Reviews Genetics 13(3):153-62.

De, S. (2011) Somatic mosaicism in healthy human tissues. Trends in Genetics 27(6):217-23.

Der, Spiegel (2010) Der Sieg uber die Gene, http://www.spiegel.de/spiegel/print/d-73109479. html.

Doolittle, W.F. (2013) Is junk DNA bunk? A critique of ENCODE. Proceedings of the National Academy of Sciences U S A. 110(14):5294300.

Dupras, C., Ravitsky, V. and Williams-Jones, B. (2012) Epigenetics and the environment in bioethics. Bioethics. online 1 October, doi: 10.1111/j.1467-8519.2012.02007.x.

Dupre, J. (2012) Processes of Life: Essays in the Philosophy of Biology. Oxford: Oxford University Press.

Ebrahim, S. (2012) Epigenetics, the next big thing. International Journal of Epidemiology 41(1):1-3.

Elman, J., Bates, E.A., Johnson, M.H., Karmiloff- Smith, A., Parisi, D. and Plunkett, K. (1996) Rethinking Innateness: A Connectionist Perspective on Development. Cambridge, MA: MIT Press.

Engelhardt, Jr.H.T. and Caplan, A.L. (eds.) (1987) Scientific Controversies: Case Studies in the Resolution and Closure of Disputes in Science and Technology. Cambridge, UK: Cambridge University Press.

Feinberg, A.P. (2008) Epigenetics at the epicenter of modern medicine. JAMA 299(11):1345- 50.

Fortun, M. (2005) For an ethics of promising, or: A few kind words about James Watson. New Genetics and Society 24(2):157-74.

Fortun, K. and Fortun, M. (2005) Scientific imaginaries and ethical plateaus in contemporary U.S. toxicology. American Anthropologist 107(1):43-54.

Foucault, M. (1988) Technologies of the self. In: L.H. Martin, H. Gutman and P. Hutton (eds.) Technologies of The Self. A Seminar with Michel Foucault. Amherst, MA: University of Massachusetts Press.

Fraga, M.F. et al (2005) Epigenetic differences arise during the lifetime of monozygotic twins. Proceedings of the National Academy of Sciences, USA 102(30):10604-9.

Francis, R. (2011) Epigenetics: The Ultimate Mystery of Inheritance. New York: W.W. Norton.

Fujimura, J.H. (2003) Future imaginaries: Genome scientists as socio-cultural entrepreneurs. In: A. Goodman, D. Heath and S. Lindee (eds.) Genetic Nature/Culture: Anthropology and Science Beyond the Two Culture Divide. Berkeley, CA: University of California Press, pp. 176-199.

Gramsci, A. and Forgacs, D. (1988) An Antonio Gramsci Reader: Selected Writings, 1916– 1935. New York: Schocken.

Graur, D., Zheng, Y., Price, N., Azevedo, R.B., Zufall, R.A. and Elhaik, E. (2013) On the immortality of television sets: “Function” in the human genome according to the evolution-free gospel of ENCODE. Genome biology and evolution PMID, online first 20 February; doi:10.1093/ gbe/evt028.

Griesemer, J. (2002) What is ‘epi’ about epigenetics? Annals of the New York Academy of Sciences 981(1):97-110.

Griffiths, P. and Stotz, K. (2013) Genetics and Philosophy. Cambridge, UK: Cambridge University Press.

Guthman, J. and Mansfield, B. (2013) The implications of environmental epigenetics: A new direction for geographic inquiry on health, space, and nature-society relations. Progress in Human Geography 37(4):486-504.

Haig, D. (2004) The (dual) origin of epigenetics. Cold Spring Harbor Symposia on Quantitative Biology 69(1):67-70.

Haig, D. (2012) The epidemiology of epigenetics. International Journal of Epidemiology 41(1):13-6.

Hallgrimsson, B. and Hall, B. (eds.) (2011) Epigenetics: Linking Genotype and Phenotype in Development and Evolution. Berkeley, CA: University of California Press.

Hedgecoe, A. and Martin, P (2003) The drugs don’t work: Expectations and the shaping of pharmacogenetics. Social Studies of Science 33(3):327- 64.

Hedlund, M. (2012) Epigenetic responsibility. Medicine Studies 3(3):171-83.

Hurd, P. (2010) The era of epigenetics. Briefings in Functional Genomics 9(5-6):425-8.

Hyman, S. (2009) How adversity gets under the skin. Nature Neuroscience 12(3):241-3.

Keller, E.F. (2000) The Century of the Gene. Cambridge, MA: Harvard University Press.

Keller, E.F. (2010) The Mirage of a Space between Nature and Nurture. Durham, NC: Duke University Press.

Keller, E.F. (2011) Genes, genomes, and genomics. Biological Theory 6(2):132-40.

Kroeber, A. (1917) The superorganic. American Anthropologist 19(2):163-213.

Kuzawa, C. and Sweet, E. (2009) Epigenetics and the embodiment of race: Developmental origins of US racial disparities in cardiovascular health. American Journal of Human Biology 21(1):2-15.

Jablonka, E. and Lamb, M. (2005) Evolution in Four Dimensions. Cambridge, MA: MIT Press.

Jasanoff, S. (ed.) (2004) States of Knowledge: The Co-Production of Science and the Social Order . London: Routledge.

Jasanoff, S. and Kim, S.H. (2009) Containing the atom: Sociotechnical imaginaries and nuclear power in the United States and South Korea. Minerva 47(2):119-46.

Jirtle, R. (2012) Epigenetics: How Genes and Environment Interact. Lecture delivered at the NIH Director’s Wednesday Afternoon Lecture Series 18 April, http://randyjirtle.com/media?id=2, accessed 1 November 2013.

Landecker, H. (2011) Food as exposure: Nutritional epigenetics and the new metabolism. BioSocieties 6(2):167-94.

Landecker, H. and Panofsky, A. (2013) From social structure to gene regulation, and back: A critical introduction to environmental epigenetics for sociology. Annual Review of Sociology 39(July):333-57.

Latour, B. (1999) Pandora’s Hope: Essays on the Reality of Science Studies. Cambridge, MA: Harvard University Press.

Latour, B. (2004) Why has critique run out of steam? From matters of fact to matters of concern. Critical Inquiry 30(2):225-48.

Lewkowicz, D.J. (2011) The biological implausibility of the nature–nurture dichotomy & what it means for the study of infancy. Infancy 16(4):331-67.

Ligtenberg, M.J. et al. (2009) Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3. exons of TACSTD1. Nature Genetics 41(1):112-17.

Lock, M. (2012) The epigenome and nature/ nurture reunification: A challenge for anthropology. Medical Anthropology 32(4): 291- 308.

Logan, C. and Johnston, T. (2007) Synthesis and separation in the history of ‘nature’ and ‘nurture’. Developmental Psychobiology 49(8):758-69.

Loi, M., Del Savio, L. and Stupka, E. (2013) Social epigenetics and equality of opportunity. Public Health Ethics 6(2):142-53.

Loke, Y.J. (2013) The peri/postnatal epigenetic twins study (PETS). Twin Research and Human Genetics 16(1):13-20.

Maher, B. (2008) Personal genomes: The case of the missing heritability. Nature 456(7218):18-21.

Malabou, C. (2008) What Should We Do With Our Brain? New York: Fordham University Press.

Mameli, M. (2005) The inheritance of features. Philosophy of Biology 20(2-3):365-99.

Martin, B. (2008) The globalisation of scientific controversy. Globalization, 7 (1), online, http:// www.uow.edu.au/~bmartin/pubs/08globalization. html, accessed 1 November 2013.

Martin, P., Brown, N. and Kraft, A. (2008) From bedside to bench? Communities of promise, translational research and the making of blood stem cells. Science as Culture 17(1):29-41.

Martin, B. and Richards, E. (1995) Scientific knowledge, controversy and public decision making. In: S. Jasanoff, G.E. Markle, J.C. Petersen and T. Pinch (eds.) Handbook of Science and Technology Studies. Newbury Park, CA: Sage, pp. 506–26.

Martens, J.H., Stunnenberg, H.G. and Logie, C. (2011) The decade of the epigenomes? Genes Cancer 2(6):680-87.

McGowan, P. et al (2009) Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nature Neuroscience 12(3):342-8.

McGowan, P.O. and Szyf, M. (2010) The epigenetics of social adversity in early life: Implications for mental health outcomes. Neurobiology of Disease 39(1):66-72.

McGuinness, D. et al (2012) Socio-economic status is associated with epigenetic differences in the pSoBid cohort. International Journal of Epidemiology 41(1):151-60.

Mclaughlin, M. (2012) Babies born into poverty are damaged forever before birth. The Scotsman 24 January.

Meaney, M.J. (2001a) Nature, nurture, and the disunity of knowledge. Annals of the New York Academy of Sciences 935(1):50-61.

Meaney, M. (2001b) Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annual Review of Neuroscience 24(1):1161-92.

Meaney, M. (2010) Epigenetics and the biological definition of gene X environment interactions. Child Development 81(1):41-79.

Meloni, M. (2013) Biology Without Biologism: Social Theory in a Postgenomic Age. Sociology, online first 31 October; doi: 10.1177/0038038513501944.

Meloni, M. (2014) How Biology Became Social and What It Means for Social Theory, The Sociological Review, online first 26 March, doi: 10.1111/1467-954X.12151.

Mill, J. and Heijmans, B.T. (2013) From promises to practical strategies in epigenetic epidemiology. Nature Reviews Genetics 14(8): 585-94.

Miller, G. (2010) The seductive allure of behavioral epigenetics. Science 329(5987):24-7.

Morange, M. (1997) The transformation of molecular biology on contact with higher organisms, 1960–1980: From a molecular description to a molecular explanation. History and Philosophy of the Life Sciences 19(3):369-93.

Morange, M. (2002) The relations between genetics and epigenetics. Annals of the New York Academy of Sciences 981(1):50-60.

Morange, M. (2006) Post-genomics, between reduction and emergence. Synthese 151(3):355-60.

Moss, L. (2003) What Genes Can’t Do. Cambridge MA: MIT Press.

Nanney, D. (1958) Epigenetic control systems. Proceedings of the National Academy of Sciences of the United States of America 44(7):712-17.

Nature Editorial (2012) Life stresses. Nature 490:143.

Nelkin, D. (1979) Controversy: Politics of Technical Decisions. Newbury Park, CA: Sage.

Nelkin, D. (ed.) (1992) Controversy: Politics of Technical Decisions. 3rd edn. Newbury Park, CA: Sage.

Nerlich, B. and Stelmach, A. (2013) Epigenetics: Metaphors beyond genetics? Paper presented at Conference on ‘Science and Metaphor’ at the University of Flensburg, Germany, 18 October.

Nestler, E. (2013) Epigenetic inheritance: Fact or fiction? Report on Progress, The Dana Foundation April, http://www.dana.org/news/ features/detail_rop.aspx?id=42636, accessed November 2013.

Niewohner, J. (2011) Epigenetics: Embedded bodies and the molecularisation of biography and milieu. BioSocieties 6(3):279-98.

Noble, D. (2006) The Music of Life: Biology beyond the Genome. Oxford: Oxford University Press.

Nowotny, H. and Testa, G. (2011) Naked Genes, Reinventing the Human in the Molecular Age. Cambidge, MA: MIT Press.

Oyama, S., Griffiths, P.E. and Gray, R.D. (2001) Cycles of Contingency: Developmental Systems and Evolution. Cambridge, MA: MIT Press.

Paul, A.M. (2010) Origins: How the Nine Months before Birth Shape the Rest of Our Lives. New York: Free Press, p. 201.

Pembrey, M. (2002) Time to take epigenetic inheritance seriously. European Journal of Human Genetics 10(11):669-70.

Pembrey, M.E. et al (2005) Sex-specific, male-line transgenerational responses in humans. European Journal of Human Genetics 14(2):159- 66.

Petronis, A. (2010) Epigenetics as a unifying principle in the aetiology of complex traits and diseases. Nature 465(7299):721-27.

Pickersgill, M., Niewohner, J., Muller, R., Martin, P. and Cunningham-Burley, S. (2013) Mapping the new molecular landscape: Social dimensions of epigenetics. New Genetics and Society 32(4):429-47.

Pigliucci, M. and Muller, G.B. (2010) Evolution: The Extended Synthesis. Cambridge, MA: MIT Press.

Poduri, A., Evrony, G., Cai, X. and Walsh, C. (2013) Somatic Mutation, genomic variation, and neurological disease. Science 341(6141):1237758.

Pray, L. (2004) Epigenetics: Genome, meet your environment. The Scientist 18(13):14.

Ptashne, M. (2007) On the use of the word epigenetics. Current Biology 17(7):R233-36.

Qiu, J. (2006) Unfinished symphony. Nature 441(7090):143-45.

Relton, C. and Davey Smith, G. (2012) Is epidemiology ready for epigenetics? International Journal of Epidemiology 41(1):5-9.

Rheinberger, H.J. (2003) Gene Concepts. Fragments from the perspective of molecular biology. In: P. Beurton, R. Falk and H.J. Rheinberger (eds.) The Concept of the Gene in Development and Evolution. Historical and Epistemological Perspectives. Cambridge, UK: Cambridge University Press, pp. 219-39.

Richardson, S. (forthcoming) Maternal bodies in the postgenomic order: Gender and the explanatory landscape of epigenetics. In: S. Richardson and H. Stevens (eds.) Postgenomics. Durham, NC: Duke University Press.

Robert, J.S. (2004) Embriology, Epigenesis and Evolution: Taking Development Seriously . Cambridge, UK: Cambridge University Press.

Ronan, J., Wu, W. and Crabtree, G. (2013) From neural development to cognition: Unexpected roles for chromatin. Nature Reviews Genetics 14(5):347-59.

Roosth, S. and Silbey, S. (2009) Science and technology studies: From controversies to posthumanist social theory. In: B.S. Turner (ed.) The New Blackwell Companion to Social Theory. Oxford: Wiley-Blackwell.

Rose, N. (2007) The Politics of Life Itself: Biomedicine, Power, and Subjectivity in the Twenty-first Century. Princeton, NJ: Princeton University Press.

Rothstein, M., Cai, Y. and Marchant, G. (2009) The ghost in our genes: Legal and ethical implications of epigenetics. Health Matrix 19(1):1- 62.

Schlichting, C.D. and Pigliucci, M. (1998) Phenotypic Evolution: A Reaction Norm Perspective . Sunderland, MA: Sinauer Associates.

Shenk, D. (2010) The Genius In All Of Us: The New Science Of Genes, Talent And Human Potential . London: Icon.

Shostak, S. (2005) The emergence of toxicogenomics: A case study of molecularization. Social Studies of Science 35(3):367.

Shulevitz, J. (2012) Why fathers really matter. The New York Times 8 September.

Singh, I. (2012) Human development, nature and nurture: Working beyond the divide. BioSocieties 7(3):308-21.

Spector, T. (2012) Identically Different: Why You Can Change Your Genes. London: Hachette.

Star, S. and Griesemer, J.R. (1989) Institutional ecology, ‘translations’ and boundary objects: Amateurs and professionals in Berkeley’s museum of vertebrate zoology, 1907–39. Social Studies of Science 19(3):387-420.

Stocking, G. (1968) Race, Culture and Evolution. New York: Free Press.

Stotz, K. (2006) With genes like that, who needs an environment? Postgenomics’ argument for the ontogeny of information. Philosophy of Science 73(5):905-17.

Stotz, K. (2008) The Ingredients for a postgenomic synthesis of nature and nurture. Philosophical Psychology 21(3):359-81.

Stotz, K., Bostanci, A. and Griffiths, P.E. (2006) Tracking the shift to ‘post-genomics’. Community Genetics 9(3):190-96.

Sunder Rajan, K. (2006) Biocapital: The Constitution of Post-Genomic Life. Durham and London: Duke University Press.

Sweatt, J.D. (2013) The emerging field of neuroepigenetics. Neuron 80(3):624-32.

Sweatt, J.D., Meaney, M.J., Nestler, E.J. and Akbarian, S. (2013) Epigenetic Regulation in the Nervous System. New York: Elsevier.

Szyf, M. (2011) DNA methylation, the early-life social environment and behavioral disorders. Journal of Neurodevelopmental Disorders 3(3):238-49.

Takahashi, K. and Yamanaka, S. (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126(4):663-76.

Tolwinski, K. (2013) A new genetics or an epiphenomenon? Variations in the discourse of epigenetics researchers. New Genetics and Society 32(4):366-84.

Tomasi di Lampedusa, G. ([1958] 1960) The Leopard (translated by A. Colquhoun) New York: Pantheon Books.

Toyokawa, S., Uddin, M., Koenen, K.C. and Galea, S. (2012) How does the social environment ‘get into the mind’? Epigenetics at the intersection of social and psychiatric epidemiology. Social Science & Medicine 74(1):67-74.

Tsankova, N., Renthal, W., Kumar, A. and Nestler, E. (2007) Epigenetic regulation in psychiatric disorders. Nature Reviews Neuroscience 8(5):355-67.

Tutton, R. (2011) Promising pessimism: Reading the futures to be avoided in biotech. Social Studies of Science 41(3):411-29.

Urnov, F.D. and Wolffe, A.P. (2001) Above and within the genome: Epigenetics past and present. Journal of Mammary Gland Biology and Neoplasia 6(2):153-67.

Van Lente, H. (1993) Promising Technologies . Delft, the Netherlands: Eburon.

Van Lente, H. (2012) Navigating foresight in a sea of expectations: Lessons from the sociology of expectations. Technology Analysis & Strategic Management 24(8):769-82.

Van Lente, H., Spitters, C. and Peine, A. (2013) Comparing technological hype cycles: Towards a theory. Technological Forecasting and Social Change 80(8):1615-28.

Van Speybroeck, L. (2002) From epigenesis to epigenetics: The case of C. H. Waddington. Annals of the New York Academy of Sciences 981:61-81.

Waddington, C.H. (2012) The epigenotype. International Journal of Epidemiology 41(1):10-3.

Wastell, D. and White, S. (2012) Blinded by neuroscience: Social policy, the family and the infant brain. Families, Relationships and Societies 1(3):397-414.

Waterland, R.A. and Jirtle, R.L. (2003) Transposable elements: Targets for early nutritional effects on epigenetic gene regulation. Molecular and Cellular Biology 23(15):5293-300.

Waterland, R.A. and Jirtle, R.L. (2004) Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 20(1):63-8.

Weaver, I. et al (2004) Epigenetic programming by maternal behavior. Nature Neuroscience 7(8):847-54.

Wells, J. (2010) Maternal capital and the metabolic ghetto: An evolutionary perspective on the transgenerational basis of health inequalities. American Journal of Human Biology 22(1):1-17.

West-Eberhard, M.J. (2003) Developmental Plasticity and Evolution. Oxford: Oxford University Press.

Wild, C. (2012) The exposome: From concept to utility. International Journal of Epidemiology 41(1):24-32.

Wintour, P. (2013) Genetics outweighs teaching, Gove adviser tells his boss. The Guardian . Friday, 11 October.




DOI: http://dx.doi.org/10.24855/biosfera.v7i4.129

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